Fig 2—Affected glomerulus stained with anti-mink C3. C3 is deposited along the basement membranes and mesangial areas. A similar pattern was seen with anti-mink IgG.

the virus remains present in the high titer.’4 These findings further incriminate the immune response of the host in the development of lesions in this disease.

Comparison with Human Disease

Some human diseases are caused by or have been suggested to be the result of persistent viral infections. These include such conditions as infectious hepatitis, subacute sclerosing panencephalitis, kuru, Creutzfeld-Jakob

Fig 3—Fibrinoid necrosis of small muscular artery in the kidney. There is perivascular infiltration of mononuclear cells (principally plasma cells) and neutrophils within the necrotic media.